Pipeline and Goals

The following projects represent our 1-3 year initiative for discovery and innovation to impact the ALS community.

Detailed Longitudinal EMG Study

Using the Foundation’s Pilot study as a guide with respect to our unique findings and use of multibaric systems, other researchers must validate our initial results and also expand upon the understanding of cellular adaptation using these multi-baric systems.

The study should involve both EMG and surface mount EMG, in addition to nerve conduction studies (NCS)

Biomarkers - Genomic and Proteomic

The Foundation will endeavor to help orchestrate and fund multiple Genomic and Proteomic studies dealing with enhanced cellular survival, cellular communication, cross-talk pathways, and cellular adaptation. The following is a starting list for discovery:

  • HIF-1α - Hypoxia-inducible factor 1-alpha

  • mTor - Mammalian target of rapamycin (Regulator of mitochondrial function and mitochondrial biogenesis)

  • cfRNA - cell free RNA exosomal signalling

  • IGF-BP7 (Insulin Growth Factor Binding Protein-7) regulation IGF-1 receptor and Insulin Recpetors

  • Cytoskeleton integrity - Microtubules (α/β-tubulin) active polymerization and de-polymerizatrion - highly dynamic polar filaments

Biophysical Review of Dynamics

While the concept of multi-baric systems appear simple, the actual dynamics of external forces with partial pressure gas exchanges are quite complex on biological and molecular systems.

With the use of this unique instrument (multibaric systems) researchers will have a controlled dynamic environment to conduct research.

Control - Performance Athletes

Scientific reports have shown that multi-baric systems have consistently demonstrated an increase in max VO2 performance. This performance increase is on the genomic level.

The control phase of this study will perform a longitudinal study on both the genomic and proteomic changes that occur.