Mission
Our goal is to provide evidence-based support using technology that can improve the outcomes and patient care for individuals with neuromuscular conditions.
Who We Are
The ALS Performance Research Foundation is dedicated to advancing scientific and medical knowledge to help individuals living with Amyotrophic Lateral Sclerosis and other neurodegenerative and neuromuscular conditions to achieve measurable clinical improvements.
Our goal is to enhance the quality of life for these individuals and their families by developing and applying performance analyses, monitoring, and methodologies for a vital ALS biomarker “fasciculations”. Our innovative approach emphasizes device-based therapies that work in harmony with pharmaceutical treatments, offering cutting-edge solutions for managing these challenging conditions.
What We Have
Accomplished
Collected and analyzed EMG data with an individual afflicted with lower motor neuron ALS.
Collected and analyzed EMG data with an individual afflicted with Bulbar ALS.
Collected EMG data on various anatomical regions simultaneously.
Conducted a longitudinal study of two individuals following the use of multibaric sessions.
Collected and analyzed Fasciculation Potentials spikes (FP Spikes) pre and post multibaric sessions.
Our Results
The Pilot Study confirmed, that the null hypothesis can be rejected (double negative) - “There is a significant difference between Pre-Multibaric and Post-Multibaric sessions objectively measured with surface mount EMG data”.
The Fasciculation Potentials spikes (FP spikes) decrease in a meaningful way.
New Anatomical regions have been recognized to measure the Electrophysiological signals Pre and Post multi-baric sessions.
Discovered a Unilateral Difference in Neuronal Tracts responding to post multibaric sessions.
Discovered a new EMG scoring system to measure the differences between Pre and Post multibaric sessions.
Discovered an anomaly in electrophysiological signals Post-multibaric sessions with excess Mg2+ loading that is unilateral as well.
Discovered EMG signal amplitude differences Pre and Post multibaric sessions that would easily be discarded as noise but in fact shows bimodal distribution.
First to document a decrease in Fasciculation Potentials Post multibaric sessions.
What People Are Saying
“The Foundation’s research in multi-baric technology for neurological conditions has the potential to improve lives and advance better outcomes in patients. Dr. Conidi Neurologist and board member.”
— Frank Conidi, Team Neurologist, Florida Panthers NHL
“It is noteworthy that there is no specific treatment for fasciculations, as it is symptomatic. The use of anti-epileptic drugs such as carbamazepine and phenytoin has shown a partial therapeutic response.”
— Neurol Int., August 8th, 2014
“Fasciculations are neuromuscular hyper-excitability phenomena and a hallmark symptom of ALS. No treatment today is proven to be effective against fasciculations.”
— Muscle & Nerve, March 6th, 2018